3Rs Alternatives

31B      [V. 1.] Special contributions —Plenary lectures —Carcinogenicity testing —Metabolism-mediated effects —Genomics, proteomics and gene regulation —Embryonic stem cells —Use of reconstituted tissues and co-cultures —Barrier systems in vitro —Biocompatibility of materials —Validation of alternative methods —Regulatory acceptance… 더 보기 »Progress In The Reduction, Refinement And Replacement of Animal Experimentation

31A     [V. 1.] Special contributions —Plenary lectures —Carcinogenicity testing —Metabolism-mediated effects —Genomics, proteomics and gene regulation —Embryonic stem cells —Use of reconstituted tissues and co-cultures —Barrier systems in vitro —Biocompatibility of materials —Validation of alternative methods —Regulatory acceptance… 더 보기 »Progress In The Reduction, Refinement And Replacement of Animal Experimentation

Preface ……………………………………………………………………………………………………………. vContributors ………………………………………………………………………………………………… xiiiCH. 1. Alternative Method of Assessing Toxicity,Chris K. Atterwill ………………………………………………………………………. 1PART I: TARGET ORGAN TOXICITYCH. 2. LLC-RK1 Cell Screening Test for Nephrotoxicity,David J. White and Chris Seaman …………………………………………….. 11CH. 3. Preparation and Use of Cultured Astrocytes… 더 보기 »In vitro Toxicity Testing Protocols

A progress report from The Johns Hopkins Center For Alternatives To Animal Testing   A Receptor Binding Techniques in Drug Development 3B Development of In Vitro Techniques to Measure the Inflammatory Response 23CytotoxicityAcute Toxicity 93

Preface ……………………………………………………………………… xi1. The future for acute oral toxicity testing ….. …… …….. ………. …. 1D. G. Clark, R. Fielder, C. Joseph, J. Gardner and M. SmithIntroduction . . . . . . . . . . . . .… 더 보기 »Animals And Alternatives in Toxicology

CONTENTS AcknowledgementsI IntroductionII Aspects of PainIII Behavior ExperimentsIV CancerV ImmunologyVI Inhalation of Toxic SubstancesVII The Plight of the Nonhuman PrimateVIII RadiationIX Surgical ExperimentsX Tetratogen TestingXI Testing Biological ProductsXII Toxicity Test Procedures for Chemical SubstancesXIII Testing Specific ChemicalsXIV Therapies of Tomorrow

Animal experimentation has long been a controversial issue with impassioned arguments on both sides of the debate. Increasingly it has become more expedient and feasible to develop new methods that avoid the use of animals. There is agreement on both… 더 보기 »Alternatives to Animal Testing