Progress In In Vitro Toxicology
Part One: Sympopsium Presentations
Epidermal Toxicity
Skin Toxicity
L.A. Goldsmith
Proteinase Biology in Keratinocyte Culture: Possible Utility as a Model for Toxicological Testing
G.S. Lazarus
Testskin: A Hybrid Organism Covered by a Living Human Skin Equivalent DEsigned for Toxicity and Other Testing
E. Bell, N.L. Parenteau, H.B. Haimes, R.J. Gay, P.D. Kemp, T.W. Fofonoff, V.S. Mason, D.T. Kagan, and M. Swiderek
Cellular Responses of Cultured Human Epidermal Keratinocytes as Models of Toxicity to Human Skin
S.T. Boyce, J.F. Hansborough, and D.A. Norris
Surfactant-Induced Cutaneous Primary Irritancy: An In Vitro Model – Assay System Development
V. DeLeo, J. Hong, S. Schiede, B. Kong, S. De Salva, and D. Bagley
Summary of Panel Discussion
Y. Gressel
Recent Advances in Tissue Culture
Introduction
P. Ward
Cultured Endothelial Cells as Probes for In Vitro Biology
U.S. Ryan and J.M. Vann
Cultured Rat Hepatocytes in the Study of the Hepatoxicity of Acetaminophen
J.L. Farber
Update: A Critical Evaluation of Alternatives to Acute Ocular Irritancy Testing
J.M. Frazier
Biotechnology and In Vitro Toxicology
Issues in the Dafety Assessment of Products of Biotechnology
G. Zbinden
Recombitant DNA and Monoclonal Antibody Products
R.E. Stoll
Tests for Worker Exposure to Products of Biotechnology
D.K. Flaherty, P.A. Winzenburger, and P.L. Sherman
Summary
R.A. Scala
Part 2: Poster Presentations
Poster Presentations
Functional Characteristics of Proximal Tubule Cells in Primary Culture: A New In Vitro Model for Studying Nephrotoxocity
M.D. Aleo and P.J. Kostyniak
Structure-Activity Relationship of Inorganic Metals, Organometals, and Organic Test Agents Determined In Vitro with the Neutral Red Assay
H. Babich and E. Borenfreund
An Imrproved CAM Assay for Predicting Ocular Irritation Potential
D.M. Bagley, P.Y. Rizvi, B.M. Kong, and S.J. De Salva
The Effects of Hyperoxic and Hypoxic Exposure on Catalase in Mouse Skin Explants
M.G. Bird, G. Witz, R.A. Scala, and D.V. Parke
Prediction of the Eye Irritation Potential of Surfactant-Based Household Cleaning Products Using the SIRC Cell Toxicity Test
J. Demetrulias and H. North-Root
Differential Response of In Vitro Vaginal Tissue to Various Test Agents
N.H. Dubin, R.B. Ghodgaonkar, and T.H. Parmley
Use of Isolated Hepatocytes for Studying the Biochemical Mechanisms of Steatosis and Cholestasis
F. Goethals, D. Deboyser, C. Gonzalez, and M. Roberfroid
The Use of Freshly Isolated Hepatocytes for Studying Toxicity of Drug Mixtures
F. Goethals, P. Vossen, M.-N. Blaude, and M. Roberfroid
Comparative Hazard Assessment of Formaldehyde and Trioxane In Vitro Using Human Diploid Cell Strains
R.A. Kreiger and V.F. Garry
High Performance Liquid Chromatography Analysis of the Novel Neutrophil Chemoattractants “Nourin” Released from Alkali-Burned Corneas
F. Metwally, A. Cohen, E.F. Rossomando, and S.A. Elgebaly
Acute and Protracted Injury to Corneal Epithelium as an Indication of the Biocompatibility of Various Pharmaceutical Vehicles
D.R. Meyer and J.P. McCulley
In Vitro Toxicology Data on Respirable Particles and Fibres and Its Evaluation for Statistical Significance
D. Nadeau, D. Paradis, L. Fouquette, and J. Dunnigan
In Vitro Ocular Irritancy Prediction: Assays in Serum-Free Media Correlate Better with In Vivo Data
C. Shopsis and b. Eng
The MTT In VitroCytotoxicity Test: Correlation with Cutaneous Irritancy in Two Animal Models
D.A. Swisher, M.E. Prevo, and P.W. Ledger
Trans-Epithelial Permeability of Fluorescein In Vitro as an Assay to Determine Eye Irritants
R. Tcaho
In Vitro Cytotoxicity Test Using Primary Cells Derived from Rabbit Eye Is Useful as an Alternative for Draize Testing
M. Watanabe, K. Watanabe, K. Suzuki, O. Nikaido, T. Sugahara, I. Ishii, and H. Konishi
Evaluation of Organic Nephrotoxins Using Rabbit Renal Cortical Slices
G.H.I. Wolfgang, A.J. Gandolfi, C.L. Krumdieck, and K. Brendal
A Rapid and Reliable Acute Toxicity Test for Hepatotoxic Agents Using Only a Single Animal
U. Wormser and D. Calp
Commercial Poster Presentations
The EYTEX-MPA System: An In Vitro Method for the Evaluation of Ocular Safety
V.C. Gordon and H.C. Bergman
External Evaluation of the Standard EYTEX System in Six Laboratories to Determine Intra- and Inter-Laboratory Accuracy and Precision
V.C. Gordon and H.C. Bergman
External Evaluation of the EYTEX and EYTEX-MPA Systems in Twelve Laboratories to Determine the Correlation of EYTEX Results with In Vivo Results
V.C. Gordon and H.C. Bergman
Current Uses of Normal Human Epidermal Keratinocytes in Serum-Free Medium for In Vitro Toxicology
P.T. Wagner