In Vitro Toxicology : Mechanisms and New Technology
Part One: Symposium Presentations
Mechanisms of Tissue Injury
Arachidonic Acid Metabolites and Phagocytic Cells as Mediators of Tissue Injury
H.J. Forman and T.W. Robison
Molecular Studies of n-Hexane and Carbon Disulfide Neuropathies
D.G. Graham, W.M. Valentine, V. Amarnath, and D.C. Anthony
Avon Contact Allergy Program Project Update
Introduction to Avon Program Project
J.J. Teal
The Skin as an Immunologic Organ: Role of Epidermal Cytokines
D.N. Auder and C. Feliciani
Application of Molecular Biology and Genetics to In Vitro Toxicology
Stimulation of Cell Proliferation by Tumor Promoters
J.D. Yager
Molecular Mechanisms of Adrenergic Responses
J.J. Onotatio
Development of an In Vitro Model System to Study the Physiologic Effects and Toxicities of Immunosuppressants
C.B. Thompson, K.M. Jackson, L.A. Turka, B.S. Mitchell, and C.H. June
Reproductive Toxicology and Teratology
In Vitro Assessment of Gamete Integrity
S.P. Darney
In Vitro Approaches to Teratology
B.F. Hales
Historical Perspectives on In Vitro Toxicology
J. Parascandola
New Technology
Cells on Silicon: The Microphysiometer
J.W. Parce, J.C. Owicki, H.G. Wada, and K.M. Kercsco
In Vitro Mutagenesis Assay Developed through Genetic Engineering
N.S. Rudolph, V.B. Reddy, and C. Wei
Extrapolation
The Role of Physiological Modeling in Reducing Animal Use in Toxicology Research
K. Krishnan and M.E. Andersen
In Vitro – In Vivo Extrapolation of Xenobiotic Metabolism
R.J. Chernery, J.P. Keogh, L.C. Rath, and P. McWilliams
An Expert System Approach to the Prediction and Elucidation of the Structural Basis of Toxicological Activities
H.S. Rosenkranz and G. Klopman
Comparative Toxicity: Mechanistic Studies on Acetaminophen Action In Vitro and In Vivo in Various Studies Including Man
C.A. Tyson, S.D. Cohen, and E.A. Khairallah
Alternative Methods for Toxicity Testing: Perspectives on Validation in Europe
B.J. Blaauboer
Update on Validation – 1990
J.M. Frazier
Part 2: Poster Presentations
Liver
Long-Term Liver Cell Cultures as Potential Substrates for Toxicity Assessment
B.A. Naughton, B. Sibanda, and G.K. Naughton
Effects of Indole Derivatives on Biotransformation Activities in Primary Cultures of Rat Hepatocytes
H.M. Wortelboer, C.A. de Kruif, F.R. Cassee, H.E. Falker, A.A.J. Wortelboer, C.A. de Kruif, F.R. Cassee, H.E. Falke, A.A.J. van Iersel, J. Noordhoek, and B.J. Blaauboer
Ocular Toxicity
An Evaluation of the SIRC Rabbit Corneal Cell System for the Estimation of Ocular Irritancy Potential
D.E. Amacher, C.V. Higgins, and R. Jayasinghe
A Comparison of the In Vitro and In Vivo Effects of Nonionic Surfactants Used in Ophthalmic Formulations
R.M. Oda, M.P. Wong, I.-M. Pride, M. Ismail, J. Andersen, C. Anger, and S. Matsumoto
Evaluation of the EYTEX System as a Screen for Eye Irritancy of Petroleum Products
T.A. Roy, K.A. Saladdin, J.J. Yang, and V.C. Gordon
Occular Irritancy Prediction via Light Scattering Measurements on Chicken Cornea
C. Shopsis, T. Zhao, and F.A. Bettelheim
EYTEX Third Generation
V.C. Gordon
The SOLATEX System, An In Vitro Method to Predict Photoirritation and Screen SPF Formation
V.C. Gordon and C.P. Kelly
Dermal Toxicity
Response of Human Cell Cultures to Cytotoxicants Requiring Metabolic Activation
H. Babich, N. Martin-Alguacil, C. Raul, D.W. Rosenberg, and E. Borenfreund
Arachidonic Acid-Release from Three Skin Culture Models in Response to Surfactant-Based Irritants
M.P. Carver, R. Reigle, and S.J. DeSalva
Rapid Structural and Functional Evaluation of Epidermal Cell Cultures Using Laser Scanning Confocal Microscopy
C. Cullander, R.H. Guy, R. Hinz, P. Biblbo, C. Nolte, L.M. Wilkins, and N.L. Parenteau
A Comparison of Four Measures of Toxicity Applied to Human Dermal Fibroblasts Grown in Three Dimensional Culture on Nylon Mesh (SKIN2 Dermal Model)
J.W. Harbell, K.A. Wallace, R.D. Curren, G.K. Naughton, and D. Triglia
Native-State Sponge-Gel Histoculture of Intact Three Dimensional Tissue for In Vitro Toxicity Assays
L. Li, L.B. Margolis, and R.M. Hoffman
Evaluation of Human Skin Cell Cultures for In Vitro Skin Irritancy Testing
R. Osborne and M.A. Perkins
Role of Epidermal Keratinocytes During Contact Allergy
F.M. Robertson and T.M Oberyszyn
Regulation of Collagen Deposition by Human Fibroblasts Grown in a Three Dimensional Skin Culture System
S.R. Slivka, L. Landeen, G.K. Naughton, and R.L. Bartel
Evaluation of an In Vitro Dermal Irritation Assay
R.J. Soto and V.C. Gordon
A Three Dimensional Human Dermal Model Substrate for In Vitro Toxicological Studies
D. Triglia, S.S. Braa, T. Donnelly, I. Kidd, and G.K. Naughton
A New Two-Compartment Skin Model for Cutaneous Toxicity Testing
J.J.M. van de Sandt, A.A.J.J.L. Rutten, and H.B.W.M. Koeter
Mechanisms of Toxicity
Difloxacin Reduces Glycosaminoglycan Sunthesis in Organ Cultures of Articular Cartilage
J. Burkhardt, M. Hill, W. Carlton, and C. Lamar
An In Vitro Assessment of Determinants of Susceptibility of Mouse Bone Marrow Stromal Cells to Hydroquinone-Induced Toxicity
L.E. Twerdok, S.J. Rembish, and M.A. Trush
Assessing Psychoative Drug Neurotoxicity In Vitro: Initial Studies Using NG108-15 Neuroblastoma-Glioma Cells
A.D. Weissman and J.E. Johnson, Jr.
Reproductive/Developmental Toxicity
Leydig Cell Primary Cultures Can Be Used to Identify Toxicants Acting to Impair or Kill Leydig Cells
W.R. Kelce, B.R. Zirkin, and L.L. Ewing
Development of New In Vitro Systems
Comparison of Cell, Tissue, and Whole Organism Bioassays to Assess Inorganic Metal Toxicity in the Aquatic Environment
A.S. Kane, R.O. Bennett, J.H. Resau, J.R. Cottrell, R. Reimschuessel, E.B. May, M. Streb, R. Hutchenson, and M.M. Lipsky
Rat Nasal Epithelial Cell Lines for In Vitro Toxicity Testing: Derivation and Partial Characterization
P.M. Mattes, W.B. Mattes, and J.B. Morris
Isolated Whole Heart and Tissue Culture Models for the Study of Arrhythmias
J. Morgan and L. Cohen
Measurement of Hematotoxicity Using Bone Marrow Cultured Alone or in the Presence of Liver Cell Cultures
B.A. Naughton, B. Silbanda, D. Triglia, and G.K. Naughton
Lucigenin-Derived Chemiluminescence as a Monitor of Mitochondrial Maturation and Modulation in Mononuclear Cells
S.J. Rembish, Y. Yang, R.L. Esterline, A. Seacoat, and M.A. Trush
Utility of Neuronal Tissue Cultures at Defence Research Establishment Suffield
T.W. Sawyer and M.T. Weiss
Other
Computer Simulation Studies of Systmeic Physiology and Pharmacology
R.L. Summers and J.P. Montani